It’s ancient Roman slavery, not modern ones, but you might look to The Gladiator: Road to the Colosseum as a good model for how to handle slavery (including the gender dynamics.) It manages to convey the absolutely soul-crushing horrors and agony of the slave trade while still being playable and engaging.
Of course, ancient Roman slavery is not nearly as much of a sensitive subject as 18-19th century slavery (most modern people can’t trace their family trees back to Roman slaves), but it shows that in principle it can be done well in a historical setting.
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