In terms of kind of stories I always enjoy, there’s something alluring about the idea of “replacing” another being - as in taking over a form already existing in the world and coping with challenges it brings. The ORPHEUS Ruse toyed with that idea, as well as some other stories on other sites, that I struggle to remember right now.
Apart from that, as a kid I loved “Honey, I Shrunk The Kids”, and would love to play a game revolving around that idea.