There’s always gonna be matters of taste involved in which characters with predetermined relationships work for which players. In general, it’s kind of unavoidable in most cases. Unless it’s the type of story where the protagonist has no memories or just doesn’t know anyone where the story takes place, you’re going to have to have known SOMEONE beforehand and had some sort of relationship with them. Friends, family, etc.
Some games can have multiple options for how you relate to certain people (like how Infinity has you determine whether or not you’re close with your family), other stories have a certain relationship that are too central to the plot and characters. Like, not every best friend character could work just as well as an enemy. Few could in fact.
A lot of people seem to think that the issue is predefined relationships (or specific types at least) in general, and while that’s sometimes true for some people, sometimes they’re focusing on the wrong issue. A lot of the times the characters themselves just don’t gel with these players so they resent being put together with them, and that’s all subjective. Sometimes the characters themselves are poorly written too, which means that the issue isn’t the pre-defined relationship but rather the character themselves not being good.