For the MC, I mean. Many (most?) games allow the player to select the MC’s gender, and selecting a gender would then set a number of variables to be compatible with that, including forms of address and pronouns. The forms of address and family relationships can come in handy, depending on what’s actually going on in the game.
How often, though, do you find yourself actually using those personal pronouns? I was scanning my WIP and I realized that it actually took forever before I used the pronouns for the MC, and that a few of the instances I used seemed… pretty contrived. For a new WIP, I’m on the verge of deciding not to set pronouns or gender at all until I reach a point where I need to use them. It’s an experiment. I’m curious to see how far I’ll get.
I know that there are a few games that don’t address the MC’s gender at all, and then there are others where gender-related worldbuilding is a major part of the game. I think my stories probably fall somewhere in the middle.