Writing discrimination towards a fictional group? Anything to be aware of in regards to similarities to actual discrimination?

[CJW]

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Please take further (civil) discussion to:

Discrimination and Escapism in Interactive Fiction

This is a spinoff from a subject that came up in “Should Hosted Games be vetted more thoroughly.” Generally, I am curious to hear people’s preferences and perspectives about the balance of writing content that deals with topics related to discrimination. I can certainly understand that when I just want some light, potentially escapist entertainment, this isn’t a theme I’d want to deal with then. But it’s also such a major theme that it can be a valuable part of literature… and interactive fic…