My personal preferences are;
Being able to choose my gender, when it actually matters. If you’re getting the same playthrough all the same then it’s not super important just sorta garnish.
I do prefer it when every RO is bi, I want to tailor my own story after all, and there’s no guarantee that I’ll fall for the ROs that were tailored for whatever gender I picked. Bioware are notorious for disapointing me in that regard. Whether the ROs are genderswaps or not doesn’t matter as long as they make me care.
I also like it when I can get with as many people as possible in one playthrough. Complications stemming from such a choice I’m prepared to accept, as long as I can always choose to juggle, e.g. no ultimatums ala you have to choose one of us unless there’s a possibillity to smooth talk your way out of it. In fiction, I like to eat my cake and have it too, or rather, eat lots of cakes. 