In my personal opinion, which I by no means want to push onto others here, dropping interest in something because of a gender/sexuality lock either way is a cop out. I have always been of the opinion that if you try you will find some form of understanding. Now that might be the roleplayer in me speaking, since I have played quite a number of PbP roleplays across the internet with quite a wide variety of characters of all stripes, and that perhaps allows me to slip into unfamiliar shoes more easily than others, but I’m sure thats only part of it. The rest comes down to a willingness to step out of your comfort zone and try to see the world through another’s shoes. However I’ll also admit that the whole “male-locked” standard in video games has turned me off a couple over the years, despite me being very male myself. No-one is perfect after all.
On another note, if TLOU2 doesn’t have us play as Ellie I will murder someone. Seriously.