Were you talking about Hera and Persephone? if so, it’s honestly hard to tell.
With Persephone, there definitely a strained awkwardness in her first interactions with a Hades Bearer that isn’t there when she first meet a Zeus/Poseidon Bearer. It was stated in-game that very few people were in the know when it came to the knowledge of who the Bearer’s father was for a while, and considering that Hera was probably one of the many who were not aware, it might be safe to say Persephone may also have not know about Hades being the Bearer’s father for a good while. And if we go by Aeson’s own words, it took her a good while to warm up to the Bestower, who was a child at the time. It’s hard to tell what exactly Persephone is feeling when meeting the Bearer for the first time (who is much older than Aeson was when he first met Persephone), but the awkwardness of the situation is clearly not lost on her. That said, Hades Bearers have been confirmed to end up with a more strained relationship in the beginning with Demeter due to their origins, so that makes this particular Bearer stuck in awkwardness with two Goddesses for a while due to their birthright.
With Hera, well, she’s practically legendary for her intense dislike of the children born from Zeus’ affairs and has never been above tormenting them, so I wouldn’t be surprised about her being pissed off from the knowledge of the Bearer being Zeus’ child. But personally, I really like the idea that, for all her hostility toward Zeus’ Demigod children, it’s going to be a Bearer who isn’t his child that’s going to rile her up the most. Because as much as she may hate to admit it out loud, Hera may be used to the Zeus children to some extent and Zeus’ constant affairs. But Zeus being interested in a child that is not tied to him in any way? That must be a new kind of insulting for her and one she might not be able to deal with as effectively due to how new of a situation that is (which may even get worse if it turns out that Zeus DOES feel some form of familial affection for the Bearer, whether they are his child or not). That said, Hera does seem to have a intense dislike of the Bearer in general, and we have yet to know how Hera herself viewed the Bearer’s mother.